Red cell distribution width in patients with diabetes and myocardial infarction: An analysis from the <scp>EXAMINE</scp> trial
نویسندگان
چکیده
Aim To determine the clinical correlates of increased red blood cell distribution width (RDW), its potential mechanistic association with multiple circulating biomarkers, and prognostic value in patients type 2 diabetes (T2D) who had a recent acute coronary syndrome. Methods We used time-updated Cox models applied to enrolled Examination Cardiovascular Outcomes Alogliptin versus Standard Care (EXAMINE) trial. Results A total 5380 were included, median age was 61 years 32% women. Patients higher RDW older, more frequently women, longer duration co-morbidities. An than 16.1% (both baseline time-updated) independently associated study primary composite outcome non-fatal myocardial infarction, stroke or cardiovascular death (time-updated adjusted HR = 1.36, 95% CI 1.16–1.61, p < .001), all-cause 2.01, 1.60–2.53, as well mortality from non-cardiovascular causes 2.67, 1.72–4.15, .001). weak-to-moderate correlation haemoglobin markers that reflected inflammation, apoptosis, fibrosis congestion. did not alter values. Conclusions is marker disease severity multitude poor outcomes, including both death. correlated modestly inflammatory, pro-apoptotic, pro-fibrotic congestion markers, levels affected by alogliptin during course
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ژورنال
عنوان ژورنال: Diabetes, Obesity and Metabolism
سال: 2021
ISSN: ['1463-1326', '1462-8902']
DOI: https://doi.org/10.1111/dom.14371